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KMID : 0363320050260010143
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Journal of Korean Oriental Internal Medicine
2005 Volume.26 No. 1 p.143 ~ p.155
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Effect of Gleditsiae Spina extract on immune cells and cytokines in OVA-induced asthmatic mice
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Song Sang-Jin
Park Yang-Chun
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Abstract
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Objective : The purpose of this research is to examine the effects of Gleditsiae Spina (GS) extract on immune cells and cytokines in ovalbumin (OVA)-induced asthmatic mice.
Methods : In vivo, C57BL/6 mice were sensitized and handicapped by OVA for 12 weeks. During this experiment, the one group was then treated with GS extract for the later 8 weeks (3 times per week) and analyzed by ELISA, flow cytometer and RT-PCR.
Results : In vivo, there were significant decreases in eosinophils, IL-4, IL-5, IL-13, IgE in BALF (bronchoalveolar lavage fluid). However, IFN-{gamma} in BALF of GS group increased significantly, compared with that of control group. Additionally, the population of CD3e-/CCR3+,;CD69+/CD3e+,;IgE+/B220+,;CD11b+/Gr-l+ cells in the GS group decreased.
Conclusion : The results of this study support a role for GS as an effective treatment for asthma in its experimental success in significantly decreasing inflammation and asthma reactions, and in increasing IFN-{gamma}, which helps prevent such reactions.
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KEYWORD
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Gleditsiae Spina, asthma, cytokine
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